Association of Microbiota and overactive bladder: A mini literature review

Document Type : Review


1 Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Department of Pathology, Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

3 Urology and Nephrology Resaerch Center, Hamedan University of Medical Sciences, Hamedan, Iran

4 Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences

5 Department of Internal Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran Iran

6 Isfahan University of Medical Sciences



Overactive bladder (OAB) is a common urinary disorder that affects both sexes. This disorder has a very strong and direct effect on the quality of personal and social life of patients. Recent advances in bacterial culture techniques and molecular testing have led to the discovery of bacteria in urine and urinary tract. These findings showed that urine and urinary tract are not sterile and contain special microbiota. Thus, the goal of this review was to answer the question of whether microbiota can lead to the overactive bladder.
In this brief review, five recent studies examining the link between microbiota and OAB were evaluated. In all of these studies, some unique bacterial strains were identified in OAB patients and identified as the cause of the OAB disease or the severity of the symptoms.
Due to the change in urinary microbiota in bladder disease and the fact that some bacterial species are specific to this disease, it can be said that microbiota is associated with OAB and can be one of the causes of it.