The relationship between graft function and liver function after kidney trasplantation : a retrospective cohort study

Document Type : Original Article


1 Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Student Research Committee, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran



After kidney transplantation several factors should be checked to predict the risk of rejection. Liver enzymes are such predicting factors so liver function test abnormalities (LFTA) can consider the rejection possibility in kidney transplant recipients (KTR).
Patients and Methods
Through a retrospective cohort study 659 KTR were studied. The source of all grafts were from deceased donors. Amongst these cases there were 67 patients who showed the significant raise in creatinine as the rejection indication. Several liver indexes like alanine transaminase (ALT), aspartate transaminase (AST), direct bilirubin (Bil D), total bilirubin (Bil T), and liver ultrasound reports, Gamma Glutamyl Transpeptidase (GGT), alkaline phosphatase (ALP), Prothrombin Time (PT) INR in addition to creatinine were examined for three six post-transplant in KTR.

Our study exposed that liver functional tests regularly had considerable statistical differents between KTR with creatinine increase and with no creatinine increase. In spite of this differnces between two groups AST, ALT and ALP serum levels were still within the normal range in both groups. The same result was seen over the direct bilirubin (Bil D), total bilirubin (Bil T).

liver function test abnormalities can not adequetly predict the rejection. Some other element should taken in to the considration like inflammation factors like erythrocyte sedimentation rate (ESR or sed rate) and C-reactive protein (CRP).