Evaluation of homeostatic agent of Microporous Polysaccharide Hemosphere in Postoperative complications on tubeless percutaneous nephrolithotomy

Document Type : Original Article

Authors

1 Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Urology research Center, Tehran University of Medical Sciences, Tehran, Iran

3 Department of Urology, Zahedan University of Medical Sciences, Zahedan-Iran

10.22034/tru.2020.257231.1047

Abstract

Background and objectives: Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery process. Plant based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) is proposed for use in surgical wound sites as an absorbable hemostat and in this study we checked its efficacy.
Methods: This study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomy (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath prior to its extraction.
Finding: The mean age of the case and control groups was 42.1±19.5 and 42.1±18.5 years, respectively. Median stone size was 11.3±1.85cm. Overall, the difference between sex, age, stone size and location was not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (P-value0.05).
Conclusion: The present study showed that MPH did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion and hospital stay.

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History

  • Receive Date: 13 November 2020
  • Revise Date: 21 November 2020
  • Accept Date: 21 November 2020

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