Vaccine production by recognizing the functional mechanisms of COVID-19

Document Type : Review

Authors

1 Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

2 Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

3 UroScience and Department of Surgery (Urology), School of Medical Sciences, University of Campinas, Unicamp, and Pontifical Catholic University of Campinas, PUC-Campinas, Campinas, São Paulo, Brazil

10.22034/tru.2020.257112.1045

Abstract

Introduction and objectives: With the rapid worldwide spread of a new coronavirus with the scientific name SARS-CoV-2 at the beginning 2020, attempts to product a vaccine started in different countries. This study aimed to review mechanisms and functions of the coronavirus protein as a basis for vaccine production.
Methods: A rapid review on available studies is conducted. Related information was extracted and summarized, compared, and discussed with regards to the coronavirus mechanisms and acts as a pathogen, including apoptosis and autophagy.
Conclusion: An overview of available information on coronavirus functional mechanisms was performed to aid researchers in development and production of vaccines against it.
Apoptosis plays a significant role in the development of the pathogenesis of various cancers, autoimmune diseases, and viral infections. In addition, Autophagy is a main intracellular path for the damage and recycling of long-lived proteins and damaged organelles.

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History

  • Receive Date: 03 April 2020
  • Revise Date: 20 April 2020
  • Accept Date: 05 May 2020

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