TY - JOUR ID - 132945 TI - Investigating the Anti-Urinary Tract Infection Effect of Cornu's Mas Extract in the Rat JO - Translational Research in Urology JA - TRU LA - en SN - AU - Guitynavard, Fateme AU - Moradi Tabriz, Hedieh AU - Samadi, Ali AU - Jazayeri, Seyed Aboozar AU - Fasihi-Ramandi, Mahdi AU - Mirzaei, Akram AU - Khoshchehreh, Mahdi AU - Abedi Yarandi, Vahid AD - Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Genetics and Molecular Medicine, Faculty of Medicine, Zanjan University of Medical, Zanjan, Iran AD - Medical Laboratory, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Pathology, University of California, Los Angeles, USA Y1 - 2021 PY - 2021 VL - 3 IS - 2 SP - 67 EP - 73 KW - Cystitis KW - Urinary Tract Infection (UTI) KW - Cornus Mas KW - animal model DO - 10.22034/tru.2021.292974.1071 N2 - Introduction: Urinary tract infection (UTI) is a common bacterial infection and usually requires antibiotics for treatment. But the antibiotic resistance is always a serious concern. So, developing some alternative medication strategies such as herbal medicine is an extreme need. Several studies have confirmed the prophylactic and also therapeutic effects of a variety of anthocyanin-containing berries for UTIs. Cornus mas which is native to Southern Europe and Southwestern Asia is also rich in anthocyanin but its effect on UTI has been not yet studied. This study aims to evaluate the effect of Cornu's mas extract in treating UTI in rat models. Methods: After inducing UTI in 18 Wistar rats, they were sub-grouped into three groups: control group, nitrofurantoin treated group (case I) and Cornus mas treated group (case II). After seven days of treatment, the UTI indicators like fever, microscopic analysis of urine, and pathological examination of the bladder were investigated. Results: Actually, UTI indicators were resolved after treatment in both treated groups (nitrofurantoin and case II). A comparison of the results between the control group and the other three groups confirmed the development of UTI in the rat model. Clinical, laboratory, and pathologic results proposed that the Cornus mas extract effects in treating UTI are not inferior to that of nitrofurantoin. Conclusion: In addition to its anti-inflammatory effects, Cornu's mas extract can be a gifted potential substitute for antibiotics in treating UTI in rat models.  UR - http://www.transresurology.com/article_132945.html L1 - http://www.transresurology.com/article_132945_a5ed327aba14e2e18d06ba154600a9c3.pdf ER -