Editorial: A urinary tract infection (UTI) starts when bacteria enter the urinary tract, bladder, and kidneys. Antibiotics are usual medications to treat a UTI and to stop symptoms like pain, burning, and an urgent need to pee. The choice of antibiotic depends on two facts: what kind of bacteria caused the infection and how severe the UTI is (1). The urine culture test will define the type of germs which caused the infection. Several antibiotics are candidates for UTIs treatment, like amoxicillin, ceftriaxone, cephalexin, ciprofloxacin, fosfomycin, levofloxacin, nitrofurantoin, and trimethoprim (2,3). Very recently, the importance of herbal medicine has been reconsidered in UTIs, and Cornu's mas juice is recommended for UTI and cancer treatment.
Cranberries (Vaccinium macrocarpon) are full of bioactive ingredients reported to affect different health benefits, ranging from an enhanced immune system and reduced contagions to decrease cardiovascular disorders and tumor inhibition (4). A study by Jensen indicated the antimicrobial impact of Cornu's mas extract (5). Medication with a flavonoid-rich fraction of Cornus mas results in tumor stop in U87, HT-29, and DU145 (6). A randomized trial by Foxman et al., indicated that between women who have gynecological operation connecting urinary catheterization, medication by Cornus mas through the postoperative time condensed the degree of UTI to 50%. The antibacterial result of Cornus mas over infection (bacterial by Escherichia coli) was considered in the new mouse model of UTI. Condensed microbial amounts were shown in the bladder. Quinic, malic, shikimic, and citric acid, the preponderant organic acids in Cornus mas, were experienced in both methods of mixture and single. The groupings of the organic acids, and the acids directed individually, had not changed the infection in the UTI model except for Cornus mas. The antibacterial outcome of the organic acids from Cornus mas on cystitis can be gained from controlling a combination of malic acid and either citric or quinic acid. The research by Jensen and his colleagues for the first time indicated that Cornu's mas juice reduces E. coli colonization of the bladder in an investigational mouse model of UTI, suggesting that the organic acids can be the most active mediators (7). A randomized clinical trial by Amsa and his colleagues in 2018 standardized more than the small amounts of Cornu's mas proanthocyanidin extracts to prevent recurrent women’s cystitis (8). An ideal dose of Cornus mas measured and uniformed in premature atrial contraction (PAC) (2 × 18.5 mg PACs/day) or a controlled dose (2 × 1 mg PACs/day). The main consequence of the trial is the mean number of new symptomatic UTIs in women over a six months follow-up during the intervention (9).
Despite the noteworthy benefit of Cornus mas, it should keep in mind that because of high oxalate content, Cornus mas can predispose to kidney stone formation, and its interaction with coumarins may cause bleeding (10,11).
Cornus mas should be included in UTI treatment armamentarium eligibility after solving the problematic issues of stone-forming and interaction with warfarin.
All authors had an equal contribution.
Special thanks to Urology Research Center (URC), Tehran University of Medical Sciences (TUMS).
Conflict of interest
All authors declare that there is not any kind of conflict of interest.
There was no funding for this research.
PAC Premature atrial contraction
UTI Urinary tract infections