The Hypothesis of the COVID-19 Role in Acute kidney Injury: A Literatures Review

Document Type : Review

Authors

Urology Research Center, Tehran University of Medical Sciences, Tehran, Iran

10.22034/tru.2020.255389.1040

Abstract

Coronavirus disease 2019 (COVID-2019) is a viral infection that mainly causes pulmonary infection but mortality usually occurred in patients have comorbidity, such as chronic kidney disease (CKD) that accounts for over 20% of mortalities, morbid obesity, immunosuppression, diabetes mellitus, hypertension, and cancer. Also, the incidence of acute kidney failure reported 5-10% in outpatient series and up to 50% in patients that need to be admitted in the intensive care unit. It is important to know that acute kidney injury (AKI) is associated with increased mortality, so this essay is going to review possible mechanisms that result in AKI. Based on the multifactorial mechanism of AKI, we should have considered probable causes of AKI and act on a stepwise manner to tackle these mechanisms and improve the ultimate prognosis of patients. Although most of the measures are supportive, in some patients such as severely ill cases cytokine storm may be attributed to the severity of symptoms, so immunomodulatory treatments could be considered to decrease AKI and consequently mortality. Among hypotheses that propose AKI; pre-renal and direct renal involvement by virus discussed in detail.

Highlights

  • Patients with COVID-19 contamination might have acute kidney injury.
  • Death is significantly higher among patients with acute renal failure.
  • The main risk factors for acute kidney injury are male sex, diabetes mellitus hypertension,cardiovascular disease.

Keywords

References

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History

  • Receive Date: 20 May 2020
  • Revise Date: 05 June 2020
  • Accept Date: 15 June 2020

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